Arrhythmias & electrophysiology
Novel Role of Human Epicardial Adipocyte–Derived SPARCL1 in Postoperative Atrial Fibrillation Following Cardiovascular Surgery
Authors' conclusion
These findings suggested that the SPARCL1, derived from epicardial differentiated preadipocytes, may be an important paracrine adipokine that regulates POAF and subsequent cardiovascular outcomes by improving myocardial redox state.
Study context
- Population
- Patients without known atrial fibrillation who underwent scheduled open-heart surgeryenrolled, of 274 patients prospectively studied
- Participants
- 149 patients
- Exposure
- Postoperative atrial fibrillation (POAF) vs non-POAF groups
- POAFn = 53
- Outcome
- POAF incidence
Main finding
As reported in the abstract
POAF occurred
53 (35.6%) patients
Observational data: associations, not effects.
Further findings
Adipokine expression in differentiated preadipocytes
- Only SPARCL1 significantly downregulated in the POAF group
Long-term adverse cardiovascular events
- Low SPARCL1 expression associated with higher risk of long-term adverse cardiovascular events after surgery
SPARCL1 mRNA vs protein
- SPARCL1 mRNA expression correlated with SPARCL1 protein concentration in culture medium
Myocardial oxidative stress (experimental)
- SPARCL1 attenuated angiotensin II-induced oxidative stress in neonatal rat myocytes
- Preadipocytes from non-POAF patients suppressed myocardial oxidative stress in coculture
Original publication
Novel Role of Human Epicardial Adipocyte–Derived SPARCL1 in Postoperative Atrial Fibrillation Following Cardiovascular Surgery. JACC Clin Electrophysiol. Published 3 July 2025. doi:10.
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