Heart failure & cardiomyopathies
Hyperlactataemia is a Marker of Reduced Exercise Capacity in Heart Failure with Preserved Ejection Fraction
Authors' conclusion
HFpEF is associated with reduced exercise capacity secondary to both central and peripheral factors that alter oxygen utilization. This results in hyperlactataemia.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF), non-cardiac dyspnoea (NCD) and healthy volunteers undergoing right heart catheterization at rest and during symptom-limited supine exercise
- Participants
- 362 patients
- Exposure
- HFpEF vs non-cardiac dyspnoea vs healthy volunteers
- HFpEFn = 198
- NCDn = 103
- Healthy volunteersn = 61reference
- Outcome
- Lactate accumulation and central haemodynamic responses to exercise
Methodological detailsinvasive exercise haemodynamics
- Invasive exercise haemodynamics
Main finding
As reported in the abstract
Exercise lactate indexed to workload
HFpEF vs NCD: P = 0.016 · HFpEF vs Healthy volunteers: P < 0.001
Observational data: associations, not effects.
Further findings
Peak workload — HFpEF vs Healthy volunteers
P < 0.001
Exercise cardiac index — HFpEF vs NCD
P < 0.001
Oxygen delivery during exercise — HFpEF vs NCD
P = 0.024
| Outcome | P value |
|---|---|
| Peak workloadHFpEF vs NCD | P = 0.85 |
| Exercise cardiac indexHFpEF vs Healthy volunteers | P < 0.001 |
| Oxygen delivery during exerciseHFpEF vs Healthy volunteers | P < 0.001 |
Predictors of higher exercise lactate in HFpEF (adjusted)
- Female sex and CKD predicted higher exercise lactate
- both P < 0.001
Original publication
Hyperlactataemia is a Marker of Reduced Exercise Capacity in Heart Failure with Preserved Ejection Fraction. ESC Heart Fail. Published 2 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →