Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study
Authors' conclusion
Genetic liability to HDPs is associated with higher CVD risk, lower blood pressure levels and earlier hypertension diagnosis.
Study context
- Population
- Ever pregnant women with available genetic data, UK Biobank (mean age 56.8 (SD 7.9) years)
- Participants
- 221,155 ever pregnant women
- Comparison
- Genetic liability to pre-eclampsia/eclampsia and gestational hypertension, per unit increase in log odds
- Outcome
- Cardiovascular disease (CVD) (MI or stroke)
Methodological detailsinverse-variance weighted regression, UK Biobank individual participant data
- Inverse-variance weighted regression
- UK Biobank individual participant data
Main finding
As reported in the abstract
Odds ratio (CI)
Pre-eclampsia/eclampsia
1.20(1.02–1.41)
Gestational hypertension
1.24(1.12–1.38)
Per unit increase in log odds, as printed
Further findings
SBP, DBP and age at hypertension diagnosis
- Genetic liability to HDPs associated with higher SBP and DBP and younger age at hypertension diagnosis
Sensitivity analyses in nulligravidae and men
- No statistically significant differences vs findings in nulligravidae and men
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study. Heart. Published 26 December 2023. doi:10.
Summarised from the published abstract; every number is checked against it