Impact of multiple obesity metrics on hypertensive disorders of pregnancy: a meta-analysis and Mendelian randomisation study
Authors' conclusion
This study demonstrates that various obesity measures are causally linked to increased HDP risk and highlights the mediating role of triglycerides.
Study context
- Population
- Pregnant women; 10 obesity measures assessed for hypertensive disorders of pregnancy (HDP) risk
- Comparison
- Obesity measures and HDP risk
- Outcome
- Gestational hypertension and pre-eclampsia (meta-analysis)
Pooled result
As reported in the abstract
Odds ratio (95% CI)
OverweightGH
1.98(1.83–2.15)
ObesityGH
3.77(3.45–4.13)
Overweightpre-eclampsia
1.78(1.67–1.90)
Obesitypre-eclampsia
3.46(3.16–3.79)
Further pooled results
Pre-eclampsia, higher maternal waist circumference (WC) (meta-analysis)
| Comparison | OR (95% CI) | |
|---|---|---|
| Higher WC | 1.45 (1.14–1.83) | |
| 0.512Odds ratio (log scale) |
Gestational hypertension (GH) and pre-eclampsia per 1-SD increase in genetically predicted obesity measures (Mendelian randomisation (MR))
- Whole body fat mass, body fat percentage, trunk fat mass, trunk fat percentage, BMI, WC, hip circumference associated with higher risks of GH and pre-eclampsia
Mediation by triglycerides
- Proportion of total genetic effect on GH and pre-eclampsia mediated by triglycerides
- 4.3%-14.1%
Original publication
Impact of multiple obesity metrics on hypertensive disorders of pregnancy: a meta-analysis and Mendelian randomisation study. Heart. Published 22 August 2024. doi:10.
Summarised from the published abstract; every number is checked against it