Heart failure & cardiomyopathies
Identification, Characterisation and Outcomes of Pre-Atrial Fibrillation in Heart Failure with Reduced Ejection Fraction
Main findingResult — go to the resultHazard ratio 3.25 95% CI 2.00–5.28Authors' conclusion
A pre-AF HFrEF subgroup with distinct CMR characteristics and poor prognosis may be identified
Study context
- Population
- Adults ≥18 years with heart failure with reduced ejection fraction (HFrEF) without atrial fibrillation (AF), MATCH 1 and MATCH 2 studies (2018–2024), all with cardiac magnetic resonance (CMR)
- Participants
- 385 adults
- Exposure
- High vs low FIND-AF risk
- Outcome
- Time to composite MACE:
- HF hospitalisation
- MI
- Stroke
- All-cause mortality
- Follow-up
- Median 2.5 years
Methodological detailsmachine learning risk stratification (FIND-AF)
- Machine learning risk stratification (FIND-AF)
Main finding
As reported in the abstract
Hazard ratio
3.25
95% CI 2.00–5.28
P < 0.001
Events by group
High FIND-AF riskvs Low FIND-AF risk
HR 3.25 (95% CI 2.00–5.28); P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | β (95% CI) | P value |
|---|---|---|
| CMR findings by higher FIND-AF scoreHigher FIND-AF score · indexed LV mass | 4.7 (0.5–8.9) | |
| CMR findings by higher FIND-AF scoreHigher FIND-AF score · indexed left atrial volume | 5.9 (2.2–9.6) | |
| CMR findings by higher FIND-AF scoreHigher FIND-AF score · indexed LV end-diastolic volume | 9.55 (1.37–17.74) | P = 0.022 |
| CMR findings by higher FIND-AF scoreHigher FIND-AF score · native T1 | 18.0 (7.0–29.1) | |
| CMR findings by higher FIND-AF scoreHigher FIND-AF score · extracellular volume | 1.6 (0.6–2.5) |
Original publication
Identification, Characterisation and Outcomes of Pre-Atrial Fibrillation in Heart Failure with Reduced Ejection Fraction. ESC Heart Fail. Published 18 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →