Arrhythmias & electrophysiology
Identifying the prognostic significance of early arrhythmia recurrence during the blanking period and the optimal blanking period duration: insights from the DECAAF II study
Authors' conclusion
Early atrial arrhythmia recurrence during the blanking period, particularly during the third month, is significantly associated with later recurrence.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) undergoing catheter ablation
- Participants
- 688 patients
- Comparison
- Early arrhythmia recurrence during the blanking period vs sinus rhythm throughout the blanking period
- Recurrence during blanking periodn = 287
- Sinus rhythmn = 401reference
- Primary endpoint
- First confirmed recurrence of atrial arrhythmia
Primary result
As reported in the abstract
Longer-term arrhythmia recurrence
P < 0.001
Further findings
- AF burden by smartphone ECG · 18 months follow-up — Sinus rhythm
- 5%
- Longer-term recurrence by timing of blanking-period recurrence: Group 1 (first month) 43.9% · HR 1.5
- Longer-term recurrence by timing of blanking-period recurrence: Group 2 (second month) 61.6% · HR 2.35
- Longer-term recurrence by timing of blanking-period recurrence: Group 3 (third month) 93.3% · HR 10.15
- Longer-term recurrence by timing of blanking-period recurrence: P < 0.001
- AF burden by smartphone ECG: Group 3 29%
- AF burden by smartphone ECG: Group 1 6%
- AF burden by smartphone ECG: Group 2 7%
- AF burden by smartphone ECG: P < 0.0001
Timing of recurrence vs primary outcome (ROC analysis)
- AUC
- 0.746
- P
- P < 0.001
- Optimal blanking period duration
- 34 days
Original publication
Identifying the prognostic significance of early arrhythmia recurrence during the blanking period and the optimal blanking period duration: insights from the DECAAF II study. Europace. Published 20 June 2023. doi:10.
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