Heart failure & cardiomyopathies
Identifying the Mechanisms of a Peripherally Limited Exercise Phenotype in Patients With Heart Failure With Preserved Ejection Fraction
Authors' conclusion
Peripherally limited patients with heart failure with preserved ejection fraction identified by cardiopulmonary exercise testing have impairments in oxygen transport and utilization at the level of the skeletal muscle quantified by invasive knee extension exercise testing, which includes an increased blood flow/V̇O2 ratio and poor muscle diffusive capacity.
Study context
- Population
- Patients with HFpEF (70±7 years, 27 females) undergoing cardiopulmonary exercise testing and invasive single leg knee extension exerciseMRS subset n=36
- Participants
- 45 patients
- Comparison
- Peripherally limited vs centrally limited HFpEF exercise phenotype
- Peripheraln = 31
- Centraln = 14reference
- Outcome
- Peak a-vO2 difference during single leg knee extension (invasive skeletal muscle O2 transport and utilization)
Main finding
As reported in the abstract
Peripheral vs Central: P = 0.013 · Peripheral vs Central: P = 0.306 · Peripheral vs Central: P = 0.024 · Peripheral vs Central: P = 0.021
Original publication
Identifying the Mechanisms of a Peripherally Limited Exercise Phenotype in Patients With Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. Published 25 July 2024. doi:10.
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