Heart failure & cardiomyopathies
Heart-Lung Interactions in Heart Failure with Preserved Ejection Fraction (HFpEF): Dynamic Hyperinflation and Exercise Pulmonary Capillary Wedge Pressure (PCWP)
Authors' conclusion
Patients with HFpEF that dynamically hyperinflate during exercise have greater PCWP as measured with reference to atmospheric pressure. The severity of hyperinflation scaled proportionally to higher exercise PCWP.
Study context
- Population
- Patients with HFpEF (71 ± 7 years, 70% female) studied at rest, 20-W and peak exercise with right heart catheterization
- Participants
- 55 patients
- Comparison
- Dynamic hyperinflation (DH) vs typical during exercise
- Outcome
- Association of DH and expiratory flow limitation (EFL) with PCWP during exercise
- Follow-up
- 20-W and peak exercise
Main finding
As reported in the abstract
PCWP
| Group | Value | PCWP at peak exercise |
|---|---|---|
| DH | 24 ± 6 mm Hg | 44 ± 9 mm Hg |
| Typical | 18 ± 6 mm Hg | 31 ± 6 mm Hg |
Value
DH24 ± 6 mm Hg
Typical18 ± 6 mm Hg
PCWP at peak exercise
DH44 ± 9 mm Hg
Typical31 ± 6 mm Hg
- DH vs Typical: P = 0.033 — 20-W exercise
- DH vs Typical: P = 0.002 — peak exercise
- Degree of dynamic inflation vs PCWP at 20-W, r2 = 0.196
- P = 0.001
- Degree of dynamic inflation vs PCWP at peak, r2 = 0.204
- P < 0.001
- Degree of dynamic inflation vs mPAP at 20-W and peak
- P < 0.001
Original publication
Heart-Lung Interactions in HFpEF: Dynamic Hyperinflation and Exercise PCWP. JACC Heart Fail. Published 26 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →