Cardio-oncology & otherCohort study
Imaging of the brain–heart axis: prognostic value in a European setting
- Retrospective cohort study
- single-centre
Authors' conclusion
In a European patient cohort where cardiovascular status is known, SNA imaging is a robust and independent predictor of all-cause mortality, but its prognostic value for MACE is less evident.
Study context
- Population
- Patients in Europe with known CV status ('at-risk' to manifest disease), without active cancer, undergoing 18F-FDG PET/CT, 2005–2019
- Participants
- 963 patients
- Exposure
- Stress-related neural activity (SNA) on 18F-FDG PET/CT vs major adverse cardiovascular events (MACE) and all-cause mortality
- Outcome
- MACE (non-fatal stroke, non-fatal MI, coronary revascularization, CV death) or all-cause mortality
- Follow-up
- Maximum 17 years
Main finding
As reported in the abstract
MACE and all-cause mortality by SNA
SNAEstimate (95% CI)P value
MACE, univariate
sub-distribution HR 1.52(1.05–2.19)
P = 0.026death, univariate
HR 2.49(1.96–3.17)
P < 0.001- MACE events
- 118 (12.3%)
- Deaths
- 270 (28.0%)
Observational data: associations, not effects.
Original publication
Imaging of the brain–heart axis: prognostic value in a European setting. Eur Heart J. Published 10 April 2024. doi:10.1093/eurheartj/ehae162
Summarised from the published abstract; every number is checked against it