Coronary disease & ACSRandomised controlled trial
Immediate or Deferred Nonculprit-Lesion Percutaneous Coronary Intervention (PCI) in Myocardial Infarction
- Randomised controlled trial
- international
- investigator-initiated
- open-label
Authors' conclusion
Among patients with STEMI who have undergone successful primary PCI, immediate iFR-guided PCI was not superior to deferred cardiac stress MRI-guided PCI of nonculprit coronary-artery lesions with respect to death from any cause, recurrent myocardial infarction, or hospitalization for heart failure at 3 years.
Study context
- Population
- Patients with STEMI and ≥1 nonculprit lesion after successful primary PCI
- Participants
- 1,146 patients
- Comparison
- iFR vs magnetic resonance imaging (MRI)
- iFRn = 558
- MRIn = 588reference
- Primary endpoint
- Composite of:
- All-cause death
- Recurrent MI
- Hospitalization for HF
- Follow-up
- 3-year follow-up
Primary result
As reported in the abstract
Hazard ratio
0.95
95% CI 0.65–1.40
P = 0.81
Events by treatment group
iFR vs MRI
HR 0.95 (95% CI 0.65–1.40); P = 0.81
Further findings
Nonculprit-lesion PCI performed
- Nonculprit-lesion PCI performed: of 556 (iFR) and 587 (MRI)
Safety
events
| Outcome | iFR | MRI |
|---|---|---|
| Serious adverse events | 145 | 181 |
Original publication
Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction. N Engl J Med. Published 28 October 2025. doi:10.1056/nejmoa2512918
Summarised from the published abstract; every number is checked against it