Coronary disease & ACSCohort study
Prevalence and Prognostic Value of Incidentally Detected Coronary Artery Calcium Using Artificial Intelligence Among Individuals With Immune-Mediated Inflammatory Diseases
- Retrospective cohort study
- 2 medical centres
Authors' conclusion
Among those with IMIDs, incidental CAC-AI was highly prevalent and significantly associated with both all-cause mortality and MACE.
Study context
- Population
- Patients 40 to 70 years of age with systemic lupus erythematosus, rheumatoid arthritis or psoriatic disease, no prior atherosclerotic CVD, who underwent routine chest computed tomography (CT), Boston, USA, 2000–2023
- Participants
- 2,546 patients
- Exposure
- CAC-AI categories
- Outcome
- All-cause mortality and MACE (nonfatal MI, coronary revascularization, nonfatal stroke or CV mortality)
- Follow-up
- Median 8.1 years
Main finding
As reported in the abstract
- CAC-AI = 1-99 · all-cause mortality
- adjusted HR 1.41; P = 0.010
- CAC-AI = 1-99 · MACE
- adjusted HR 2.05; P < 0.001
- CAC-AI ≥100 · all-cause mortality
- adjusted HR 2.45; P < 0.001
- CAC-AI ≥100 · MACE
- adjusted HR 3.24; P < 0.001
Observational data: associations, not effects.
Further findings
Prevalence of CAC-AI >0
- CAC-AI >0
- 53%
- On a statin
- 6.0%
Original publication
Prevalence and Prognostic Value of Incidentally Detected Coronary Artery Calcium Using Artificial Intelligence Among Individuals With Immune-Mediated Inflammatory Diseases. JACC Cardiovasc Imaging. Published 28 October 2025. doi:10.1016/j.jcmg.2025.08.020
Summarised from the published abstract; every number is checked against it