Heart failure & cardiomyopathiesCohort study
Heart Failure Risk Among African-American Women With an ICAM1 Missense Variant
- Cohort study (genetic association)
- pooled analysis of WHI and MESA
Authors' conclusion
ICAM1 p.K56M (rs5491) is associated with HFpEF among African-American women ≥70 years.
Study context
- Population
- African-American women in WHI and MESAWHI
- Participants
- 8,401 women
- Exposure
- rs5491 minor allele vs no allele
- Outcome
- HF and its subtypes (HFpEF) hospitalization
- Follow-up
- Over 19.2 years
Main finding
As reported in the abstract
HF or its subtypes
Minor allele frequency of rs5491
20.7%
Heart failure (HF) hospitalizations
731
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| HFpEF, women ≥70 years (subgroup) | 1.82 (1.25–2.65) | P = 0.002 | |
| 0.20.5125Hazard ratio (log scale) |
Heart failure with preserved ejection fraction (HFpEF) hospitalization, effect modification by age
- Age (continuous) modified association with HFpEF, WHI
- interaction P = 0.04
- Age modification, pooled WHI + MESA
- interaction P = 0.009
HFpEF, women ≥70 years (subgroup)
- Not associated with HFpEF risk among women <70 years
Original publication
Heart Failure Risk Among African-American Women With an ICAM1 Missense Variant. JACC Heart Fail. Published 25 March 2024. doi:10.1016/j.jchf.2024.02.002
Summarised from the published abstract; every number is checked against it