Immunomodulatory effect of different statin regimens on regulatory T-cells in patients with acute coronary syndrome: a systematic review and network meta-analysis of randomized clinical trials
Authors' conclusion
The findings of our study indicated that both high- and low-dose statin groups increased Treg frequency compared with the control group. IST demonstrated greater benefits than CST. Furthermore, statin therapy increased IL-10 and TGF-β levels and decreased IFN-γ levels.
Study context
- Population
- Patients with ACS
- Participants
- 505 patients5 randomized clinical trials (RCTs)
- Comparison
- Low-dose conventional statin therapy (CST) and high-dose intensive statin therapy (IST) vs control
- Outcome
- Frequency of Tregs (and associated cytokines IFN-γ, IL-10, TGF-β)
Methodological detailsrandom-effects model, Grading of Recommendations, Assessment, Development and Evaluations (GRADE), RCTs published until June 2021 (PubMed, Cochrane Library, EMBASE)
- Random-effects model
- GRADE
- RCTs published until June 2021 (PubMed, Cochrane Library, EMBASE)
Pooled result
As reported in the abstract
Treg frequency
Each group vs controlSMD (95% CI)P value
CST
1.77(0.77–2.76)
P = 0.0005IST
2.12(1.15–3.10)
P < 0.0001Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| IL-10 levelsCSTvs Control | 2.69 (2.07–3.31) | P < 0.0001 | |
| IL-10 levelsISTvs Control | 2.14 (1.76–2.52) | P < 0.0001 | |
| TGF-β levelsCSTvs Control | 3.83 (0.63–7.0) | P = 0.0189 | |
| IFN-γ levelsISTvs Control | −1.52 (−1.94-1.10) | P < 0.0001 | |
| IFN-γ levelsCSTvs Control | −2.34 (−2.73-1.95) | P < 0.0001 | |
| −50510Difference (linear scale) |
TGF-β levels
- Association not seen with IST
Original publication
Immunomodulatory effect of different statin regimens on regulatory T-cells in patients with acute coronary syndrome: a systematic review and network meta-analysis of randomized clinical trials. Eur Heart J Cardiovasc Pharmacother. Published 1 September 2022. doi:10.
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