Temporal trends in major cardiovascular events following first-time myocardial infarction in the reperfusion era – a Danish nationwide cohort study from 2000 to 2017
Authors' conclusion
From 2000 to 2017, we observed a decreasing risk of recurrent MI, first-time admission for HF, and all-cause mortality in patients with a first-time MI.
Study context
- Population
- Danish patients with first-time myocardial infarction (MI), 2000–2017
- Participants
- 120,833 patients
- Exposure
- First-time MI in 2015-2017 vs 2000-2002
- Outcome
- 30-day and 1-year mortality; 1-year risk of first-time admission for HF and recurrent MI
- Follow-up
- 30 days and 1 year
Main finding
As reported in the abstract
30-day mortality, 1-year mortality, recurrent MI, first-time HF admission
2015-2017
- 30-day mortality
- 6.5%
- 1-year mortality
- 10.7%
- Recurrent MI
- 4.0%
- First-time heart failure (HF) admission
- 2.9%
2000-2002
- 30-day mortality
- 14.1%
- 1-year mortality
- 21.8%
- Recurrent MI
- 7.8%
- First-time HF admission
- 3.7%
30-day mortality
2015-20176.5%
2000-200214.1%
1-year mortality
2015-201710.7%
2000-200221.8%
Recurrent MI
2015-20174.0%
2000-20027.8%
First-time heart failure (HF) admission
2015-20172.9%
2000-20023.7%
2015-2017 vs 2000-2002Hazard ratio (95% CI)P value
30-day mortality
0.52(0.48–0.55)
P < 0.001for trend1-year mortality
0.52(0.50–0.55)
P < 0.001for trendRecurrent MI
0.56(0.51–0.62)
P < 0.001for trendFirst-time HF admission; borderline significant
0.82(0.73–0.92)
P = 0.045for trendObservational data: associations, not effects.
Further findings
PCI within 7 days after first-time MI
P for trend < 0.001
Patient characteristics
- Predominantly male
- 65.6%
- Median age declined by 3 years through the periods
Original publication
Temporal trends in major cardiovascular events following first-time myocardial infarction in the reperfusion era – a Danish nationwide cohort study from 2000 to 2017. Eur Heart J Qual Care Clin Outcomes. Published 29 August 2022. doi:10.
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