Impact of baseline risk of death or hospitalization on effectiveness of revascularization in patients with ischaemic left ventricular dysfunction—a prespecified analysis of REVIVED-BCIS2
Authors' conclusion
Baseline risk did not influence the effect of revascularization in preventing all-cause mortality or hospitalization due to heart failure. A trend was observed that lower baseline risk might be associated with more benefit of revascularization in preventing cardiovascular death or hospitalization due to heart failure.
Study context
- Population
- Patients with ischaemic cardiomyopathy263 (37.6%) had primary outcome
- Participants
- 700 patients
- Comparison
- Percutaneous coronary intervention (PCI) plus optimal medical therapy (OMT) vs OMT alone, by baseline risk
- Primary endpoint
- All-cause mortality or HF hospitalisation
- Follow-up
- Median 41 months
Methodological detailsprespecified analysis
- Prespecified analysis
Primary result
As reported in the abstract
Modification of PCI effect on primary outcome by baseline risk score
- No statistical evidence that baseline risk score modified the trial intervention effect
- pinteraction = 0.21
Secondary outcomes
Prediction model performance (12 predictors)
- C statistic
- 0.69 (95% CI 0.66-0.72)
- Calibration slope
- 0.79 (95% CI 0.64-0.95)
CV death or hospitalization due to HF, modification by baseline risk
- Weak evidence baseline risk modified the trial intervention effect; lower risk trended towards greater benefit from PCI
- P for interaction = 0.044
Original publication
Impact of baseline risk of death or hospitalization on effectiveness of revascularization in patients with ischaemic left ventricular dysfunction—a prespecified analysis of REVIVED-BCIS2. Eur Heart J Qual Care Clin Outcomes. Published 16 September 2025. doi:10.
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