Coronary disease & ACS

Three-year outcomes of A Randomized Multicentre Trial Comparing Revascularization and Optimal Medical Therapy for Chronic Total Coronary Occlusions (EuroCTO)

EuroInterventionPublished Randomised controlled trial

Authors' conclusion

At 3 years there was no difference in the rate of cardiovascular death or myocardial infarction between PCI or OMT among patients with a remaining single coronary CTO. The MACE rate was higher in the OMT group due largely to ischaemia-driven revascularisation.

Study context

Population
Patients with a symptomatic CTO; non-CTO lesions treated before randomisation
Participants
396 patients
Comparison
Percutaneous coronary intervention (PCI) vs optimal medical therapy (OMT) for CTO
Primary endpoint
CV death or nonfatal MI
Follow-up
3 years
Methodological detailsmulticentre, 3-year follow-up
  • Multicentre
  • 3-year follow-up

Primary result

As reported in the abstract

P = 0.29

Further findings

CV death or nonfatal MI, per-protocol analysis · 3 years · non-significant · per-protocol analysis

P = 0.67

MACE · 3 years

Major adverse cardiovascular events (MACE) · 3 years

More frequent with OMT, largely because of ischaemia-driven revascularisation

Safety

Stroke or hospitalisation for bleeding · 3 years

Not different between the groups

Original publication

Three-year outcomes of A Randomized Multicentre Trial Comparing Revascularization and Optimal Medical Therapy for Chronic Total Coronary Occlusions (EuroCTO). EuroIntervention. Published 18 September 2023. doi:10.4244/eij-d-23-00312

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