Heart failure & cardiomyopathies
Impact of cerebral oxygen saturation on mortality and rehospitalisation in patients with heart failure and the role of physical activity as a modifying factor: the HARVEST-Malmö Study
Authors' conclusion
Higher SctO2 at rest is associated with lower risk of all-cause mortality but it was not possible to show significant association with first-of-any rehospitalisation risk in patients with HF. Physical inactivity is associated with lower cerebral oxygen saturation at rest.
Study context
- Population
- Swedish heart failure (HF) cohort (HARVEST-Malmö)
- Participants
- 102 participants
- Exposure
- Resting SctO2
- Outcome
- All-cause mortality and first postdischarge rehospitalisation
Main finding
As reported in the abstract
Higher SctO2Hazard ratio (95% CI)P value
All-cause mortality
0.86(0.77–0.95)
P = 0.002Rehospitalisation
0.96(0.90–1.02)
P = 0.162- Deaths
- 31 (30.4%)
- Rehospitalised
- 63 (61.8%)
Observational data: associations, not effects.
Further findings
| Outcome | β (95% CI) | P value |
|---|---|---|
| SctO2 with physical inactivity (≤1 h/week strenuous activity), cross-sectionalLower SctO2 | −1.56 (−3.07 to −0.05) | P = 0.043 |
Original publication
Impact of cerebral oxygen saturation on mortality and rehospitalisation in patients with heart failure and the role of physical activity as a modifying factor: the HARVEST-Malmö Study. Heart. Published 9 December 2025. doi:10.
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