Heart failure & cardiomyopathies
Impact of Multimorbidity on Mortality in Heart Failure with Reduced Ejection Fraction: Which Comorbidities Matter Most? An Analysis of PARADIGM-HF and ATMOSPHERE
Authors' conclusion
In HF, the impact of multimorbidity differed at the individual patient and population level, depending on the prevalence of and the risk related to each comorbidity, and the interaction between individual comorbidities.
Study context
- Population
- Patients with HFrEF in the PARADIGM-HF and ATMOSPHERE trials
- Participants
- 15,066 patients
- Comparison
- Comorbidities, alone and in pairs
- Primary endpoint
- All-cause death (PAF and relative excess risk due to interaction, Cox models)
Primary result
As reported in the abstract
All-cause death by comorbidity pair
Hazard ratio (95% CI)
PAD + strokegreatest individual risk among pairs
1.73(1.28–2.33)
PAD + anaemia
1.71(1.39–2.11)
- CKD + hypertension · highest population attributable fractions (PAF)
- PAF 5.65% (95% CI 3.66–7.61)
Further findings
Prevalence of the 10 most prevalent comorbidities
- ≥1 comorbidity
- 14 133 (93.7%)
- ≥2 comorbidities
- 11 867 (78.8%)
Original publication
Impact of Multimorbidity on Mortality in Heart Failure with Reduced Ejection Fraction: Which Comorbidities Matter Most? An Analysis of PARADIGM-HF and ATMOSPHERE. Eur J Heart Fail. Published 24 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →