Arrhythmias & electrophysiology
Impact of atrial fibrillation diagnosis-to-ablation time on 24-month efficacy and safety outcomes in the Cryo Global Registry
Authors' conclusion
CBA within 12 months from AF diagnosis resulted in higher freedom from AA recurrence and is associated with fewer safety events in a real-world evaluation.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing cryoballoon ablation in the Cryo Global Registry1,220 followed through 24 months
- Participants
- 3,447 patients
- Exposure
- Early vs late cryoballoon ablation
- Earlyn = 1,573
- Laten = 1,874reference
- Outcome
- Freedom from atrial arrhythmia recurrence
- Follow-up
- 24 months
Methodological detailsmulticentre, 121 centres in 37 countries
- Multicentre
- 121 centres in 37 countries
Main finding
As reported in the abstract
Freedom from atrial arrhythmia (AA) recurrence
P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (CI) | P value | |
|---|---|---|---|
| Cardioversion41% lower risk | 0.59 (0.42–0.83) | P < 0.01 | |
| 0.512Adjusted hazard ratio (log scale) |
Safety
Serious procedure-related adverse events
P = 0.045
Original publication
Impact of atrial fibrillation diagnosis-to-ablation time on 24-month efficacy and safety outcomes in the Cryo Global Registry. Europace. Published 21 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →