Heart failure & cardiomyopathies
Impact of beta-blockers on long-term mortality in Takotsubo syndrome: a real-world analysis of the TriNetX Global Collaborative Network database
Main finding · All-cause mortality (matched cohort)Result — go to the resultRelative risk 0.67 95% CI 0.63–0.71Authors' conclusion
Beta-blocker use in patients with TTS was associated with a lower risk of short- and long-term mortality up to 5 years.
Study context
- Population
- Patients with Takotsubo syndrome (TTS) identified between 1 January 2005 and 6 June 2025, stratified by post-diagnosis beta-blocker usepatients with TTS identified, after matching, 14,268 patients in each cohort
- Participants
- 54,855 patients
- Exposure
- Post-diagnosis beta-blocker use vs control in patients with TTS
- Beta-blocker groupn = 39,108
- Controln = 15,747reference
- Outcome
- All-cause mortality (matched cohort)
- Follow-up
- 1 year
Methodological detailsPropensity-score matching using the greedy nearest-neighbour matching, TriNetX Global Collaborative Network database
- Propensity-score matching using the greedy nearest-neighbour matching
- TriNetX Global Collaborative Network database
Main finding
As reported in the abstract
Relative risk
0.67
95% CI 0.63–0.71
Beta-blocker groupvs control
RR 0.67 (95% CI 0.63–0.71)
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| All-cause mortality (matched cohort) · 3 yearsLower with beta-blocker use · matched cohort analysis | 0.78 (0.74–0.82) | |
| All-cause mortality (matched cohort) · 5 yearsLower with beta-blocker use · matched cohort analysis | 0.81 (0.76–0.84) | |
| 0.512Relative risk (log scale) |
Baseline characteristics before matching
Age beta-blocker group 71 years · control 69.7 years
White race
Baseline characteristics before matching
- Beta-blocker group had higher rates of comorbidities
Matched cohorts
- Patients in each cohort after matching
- 14 268
- Mean age
- 70 years
- Well balanced in demographics, comorbidities, medications, and laboratory data
Original publication
Impact of beta-blockers on long-term mortality in Takotsubo syndrome: a real-world analysis of the TriNetX Global Collaborative Network database. Eur Heart J Acute Cardiovasc Care. Published 18 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →