Impact of Bleeding Risk and Inflammation on Cardiovascular Outcomes After Percutaneous Coronary Intervention
Authors' conclusion
Elevated hsCRP at the time of PCI is associated with a higher risk for ischemic but not bleeding events, irrespective of HBR status.
Study context
- Population
- Consecutive patients undergoing percutaneous coronary intervention (PCI) 2012–2019 with baseline high-sensitivity C-reactive protein (hsCRP), stratified by high bleeding risk (HBR) (Academic Research Consortium criteria)6,125 HBR
- Participants
- 15,150 patients
- Exposure
- High hsCRP vs not high hsCRP, stratified by HBR status
- Outcome
- Major adverse cardiovascular and cerebrovascular events (MACCE):
- All-cause death
- MI
- Stroke
- Follow-up
- 1 year
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
MACCE, high hsCRP, by HBR subgroup
High hsCRPAdjusted hazard ratio (95% CI)
HBR
1.49(1.18–1.87)
non-HBR
1.87(1.31–2.66)
Observational data: associations, not effects.
Safety
All bleeding, high hsCRP, by HBR subgroup
| aHR (95% CI) | ||
|---|---|---|
| High hsCRPHBR | 1.04 (0.82–1.31) | |
| High hsCRPnon-HBR | 0.99 (0.71–1.39) | |
| 0.512Adjusted hazard ratio (log scale) |
- All bleeding, high hsCRP, by HBR subgroup: Pinteraction = 0.539
All bleeding, high hsCRP, by HBR subgroup
- Bleeding risk higher in the HBR cohort
Original publication
Impact of Bleeding Risk and Inflammation on Cardiovascular Outcomes After Percutaneous Coronary Intervention. JACC Cardiovasc Interv. Published 12 February 2024. doi:10.
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