Heart failure & cardiomyopathies
Impact of Cardiac Magnetic Resonance Left Atrial Ejection Fraction in Advanced Ischemic Cardiomyopathy
Authors' conclusion
Reduced LAEF is independently associated with increased mortality in ICM.
Study context
- Population
- Patients with advanced ischemic cardiomyopathy undergoing cardiac magnetic resonance (CMR) (April 2001-December 2019)416 primary events
- Participants
- 718 patients
- Outcome
- Composite of:
- All-cause mortality
- Cardiac transplant
- Follow-up
- Median 1,763 days (4.8 years)
Main finding
As reported in the abstract
All-cause mortality or cardiac transplant, by LAEF
- Higher left atrial ejection fraction (LAEF) independently associated with reduced risk (multivariable, adjusted incl. Functional mitral regurgitation (FMR) and myocardial infarct size (MIS)): HR 0.24, 95% CI 0.12-0.48, P < 0.001
- Highest adjusted risk: LAEF <20% and MIS >30%: HR 3.20, 95% CI 1.73-5.93
- Lowest risk: LAEF >50% and MIS <15% (within comparator group): HR 1.07, 95% CI 0.81-1.42
- Multivariable Cox model
Observational data: associations, not effects.
Further findings
LAEF (cohort)
- Mean LAEF 36% ± 15%
Original publication
Impact of Cardiac Magnetic Resonance Left Atrial Ejection Fraction in Advanced Ischemic Cardiomyopathy. JACC Adv. Published 4 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →