Acute cardiac care & resuscitation
Impact of Comorbidity Burden on Outcome in Patients with Cardiogenic Shock: A Cardiogenic Shock Working Group analysis
Authors' conclusion
In this large real-world CS cohort, comorbidity burden was highly prevalent, varied across subtypes, and was independently associated with mortality.
Study context
- Population
- Cardiogenic shock patients (all-cause, AMI-CS and HF-CS), Cardiogenic Shock Working Group (CSWG) registry 2020–202426.5% AMI-CS, 53.6% HF-CS
- Participants
- 6,815 patients
- Exposure
- Comorbidity burden in cardiogenic shock
- Outcome
- In-hospital mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
In-hospital mortality by comorbidity burden
1-3 comorbidities
- AMI-CS
- 35.4%
- HF-CS
- 19.6%
4-6 comorbidities
- AMI-CS
- 39.6%
- HF-CS
- 24.9%
≥7 comorbidities
- AMI-CS
- 47.1%
- HF-CS
- 27.5%
AMI-CS
1-3 comorbidities35.4%
4-6 comorbidities39.6%
≥7 comorbidities47.1%
HF-CS
1-3 comorbidities19.6%
4-6 comorbidities24.9%
≥7 comorbidities27.5%
High comorbidity burdenOdds ratio (95% CI)P value
AMI-CS, adjusted
1.51(1.02–2.23)
P = 0.037HF-CS, adjusted
2.22(1.49–3.37)
P < 0.001Observational data: associations, not effects.
Further findings
Comorbidity prevalence
- ≥1 comorbidity
- 6087 (89.3%)
- ≥3 comorbidities
- 4390 (64.4%)
Comorbidity Risk Index for Cardiogenic Shock (COMRI-CS) score
- In-hospital mortality increase per COMRI-CS point
- ≈5.5%
Original publication
Impact of Comorbidity Burden on Outcome in Patients with Cardiogenic Shock: A Cardiogenic Shock Working Group analysis. Eur J Heart Fail. Published 16 September 2025. doi:10.
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