Impact of Complete Revascularization in the ISCHEMIA Trial
Authors' conclusion
The outcomes of an INV strategy may be improved if CR (especially ACR) is achieved.
Study context
- Population
- Patients with chronic coronary disease without prior CABG randomised to invasive (INV) vs conservative (CON) in ISCHEMIA1,824 INV patients assessed
- Comparison
- Complete revascularization (anatomic complete revascularization (ACR), functional complete revascularization (FCR)) vs incomplete revascularization in INV; ACR in all INV vs CON
- INVn = 2,296
- CONn = 2,498reference
- Primary endpoint
- CV death or MI
- Follow-up
- 4 years
Methodological detailsinverse probability weighted modeling, multivariable-adjusted, independent core laboratory, ACR and FCR assessed at an independent core laboratory
- Inverse probability weighted modeling
- Multivariable-adjusted
- Independent core laboratory
- ACR and FCR assessed at an independent core laboratory
Primary result
As reported in the abstract
INV vs CONDifference (95% CI)
ACR in all INV patients, inverse probability weighted
−3.5(−7.2% to 0.0%)
- Overall ISCHEMIA trial
- event rate difference −2.4%
Original publication
Impact of Complete Revascularization in the ISCHEMIA Trial. J Am Coll Cardiol. Published 17 July 2023. doi:10.
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