Valvular & structural heart diseaseCohort study
Impact of Concomitant Mitral Regurgitation in Moderate Aortic Stenosis
- Cohort study
Authors' conclusion
Patients with moderate AS and MR constitute a high-risk subgroup with high symptom burden, adverse cardiac remodeling, and poor clinical outcomes.
Study context
- Population
- Patients with at least moderate aortic stenosis (AS) on cardiac magnetic resonance (CMR)422 moderate AS
- Participants
- 742 patients
- Exposure
- Moderate AS + mitral regurgitation (MR) vs Isolated moderate AS
- Moderate AS + MRn = 76
- Severe ASn = 320
- Outcome
- CV death or HF hospitalization
- Follow-up
- Median 1.8 years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.86
95% CI 1.31–2.65
P < 0.001
Moderate AS + MR vs Isolated moderate AS
adjusted HR 1.86 (95% CI 1.31–2.65); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Moderate AS + MR | Isolated moderate AS | Severe AS |
|---|---|---|---|
| Symptom burden and remodeling | |||
| NYHA class II-IV | 80.3% | Not reported in the abstract | Not reported in the abstract |
Symptom burden and remodeling
- Larger indexed LV volumes, lower LVEF and reduced aortic forward flow vs isolated moderate AS
CV death or HF hospitalization, by flow (subgroup)
- Risk more apparent in low-flow subgroup (stroke volume index ≤35 mL/m²); non-significant trend in normal-flow
Outcomes vs severe AS
- Worse than isolated severe AS; comparable with severe AS meeting intervention criteria
Original publication
Impact of Concomitant Mitral Regurgitation in Moderate Aortic Stenosis. JACC Cardiovasc Imaging. Published 11 June 2026. doi:10.1016/j.jcmg.2026.04.015
Summarised from the published abstract; every number is checked against it