Heart failure & cardiomyopathies
Impact of DCM-Causing Genetic Background on Long-Term Response to Cardiac Resynchronization Therapy
Authors' conclusion
Genotyping contributes to the risk stratification of patients with DCM undergoing CRT implantation in terms of LV remodeling and outcomes.
Study context
- Population
- Patients with nonischemic dilated cardiomyopathy (DCM) undergoing cardiac resynchronization therapy (CRT) with available genetic testing
- Participants
- 74 patients
- Exposure
- Genetically determined DCM vs idiopathic DCM in patients undergoing CRT
- GEN+DCMn = 25
- Idiopathic dilated cardiomyopathy (idDCM)n = 49reference
- Outcome
- Long-term LV remodeling and prevalence of super response to CRT
- Follow-up
- 24-48 months after CRT
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Super response to CRT
P = 0.025
Observational data: associations, not effects.
Secondary outcomes
HF-related death/heart transplant/LV assist device · median follow-up 55 months
P = 0.028
Original publication
Impact of DCM-Causing Genetic Background on Long-Term Response to Cardiac Resynchronization Therapy. JACC Clin Electrophysiol. Published 22 May 2024. doi:10.
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