Arrhythmias & electrophysiologyCohort study
Impact of Device Implant Depth After Left Atrial Appendage Occlusion
- Multicentre cohort study
- 9 centres in Europe and Canada
Authors' conclusion
LAAO device implantation depth is an independent risk factor for DRT. Deeper device implantation and larger uncovered left atrial appendage areas were associated with a higher incidence of DRT.
Study context
- Population
- Patients with successful left atrial appendage occlusion (LAAO) at 9 centres in Europe and Canada
- Participants
- 1,317 patients
- Exposure
- Proximal vs distal LAAO device implantation
- Proximaln = 732reference
- Distaln = 585
- Outcome
- Device-related thrombus (DRT)
- Follow-up
- follow-up
Main finding
DRT
Hazard ratio
5.92
95% CI 3.39–10.36
By group
Distal vs Proximal
HR 5.92 (95% CI 3.39–10.36)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| DRT predictor: no or single antiplatelet therapy · multivariable analysis; independent predictor | 1.62 (0.99–2.62) | |
| 0.20.5125Hazard ratio (log scale) |
Procedural outcomes
- No differences in procedural outcomes between the groups
Device-related thrombus (DRT) by implant depth and uncovered LAA area
- Deeper implantation and larger uncovered LAA area associated with higher DRT incidence, regardless of device type
- P < 0.001
Original publication
Impact of Device Implant Depth After Left Atrial Appendage Occlusion. JACC Cardiovasc Interv. Published 9 August 2023. doi:10.1016/j.jcin.2023.05.045
Summarised from the published abstract; every number is checked against it