Heart failure & cardiomyopathies
Impact of Early Intensive Guideline-directed Medical Therapy (GDMT) on Left Ventricular Ejection Fraction (LVEF) Recovery and Implantable Cardioverter-defibrillator (ICD) Decision Making in de Novo Heart Failure with Reduced Ejection Fraction (HFrEF)
Authors' conclusion
Early and intensive GDMT optimization resulted in significant LVEF improvement within the first 3 months post-diagnosis for most patients. Those who failed to recover by this point exhibited limited improvement by 1 year.
Study context
- Population
- Patients with newly diagnosed HFrEF and baseline LVEF ≤35% on early intensive GDMT, enrolled 2019–2022
- Participants
- 106 patients
- Outcome
- LVEF recovery >35%
- Follow-up
- Between 90 days and 1 year
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
LVEF recovery
- Baseline mean LVEF
- 27%
- Mean LVEF at 3 months (P < 0.001)
- 37%
- LVEF >35% at 3 months
- 58%
- Median LVEF at 12 months in those with LVEF >35% at 3 months
- 45%
- Recovered by 12 months among those with LVEF ≤35% at 3 months (n = 44)
- 8 (18%)
Observational data: associations, not effects.
Further findings
Determinants of early LVEF improvement
- Rapid initiation and optimization of GDMT, particularly angiotensin receptor-neprilysin inhibitors (ARNI) and SGLT2i, associated with early LVEF improvement
Original publication
Impact of Early Intensive GDMT on LVEF Recovery and ICD Decision Making in de Novo HFrEF. ESC Heart Fail. Published 9 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →