Pulmonary vascular disease & thromboembolism
Impact of Echocardiographic Probability of Pulmonary Hypertension on Prognosis and Outcomes Among Patients With Myeloproliferative Neoplasms
Main finding · Hematologic progressionResult — go to the resultAdjusted subhazard ratio 1.92 95% CI 1.09–3.39Authors' conclusion
Among patients with MPN, echocardiographic probability of PH was associated with an increased risk of hematologic progression. Prospective studies are needed to assess the optimal use of echocardiography on MPN-specific prognostication.
Study context
- Population
- Patients with myeloproliferative neoplasms (MPN) with ≥1 echocardiogram from 2010 to 2023237 (42.7%) had an intermediate or high probability of pulmonary hypertension (PH) on echocardiography, right heart catheterization subset n=61
- Participants
- 555 patients
- Exposure
- Echocardiographic probability of PH and hematologic progression, major adverse cardiovascular events and all-cause death
- Intermediate or high probability of PH on echocardiographyn = 237
- Outcome
- Hematologic progression
- Follow-up
- Median 51.2 months (interquartile range, 29.5-79.8)
Main finding
As reported in the abstract
Adjusted subhazard ratio
1.92
95% CI 1.09–3.39
Observational data: associations, not effects.
Further findings
Major adverse cardiovascular events · median follow-up 51.2 months (interquartile range, 29.5-79.8)
| Adjusted subhazard ratio (95% CI) | ||
|---|---|---|
| Echocardiographic probability of PHIncreased risk · Multivariable Fine-Gray competing risk regression | 1.66 (1.04–2.66) | |
| 0.20.5125Adjusted subhazard ratio (log scale) |
All-cause death · median follow-up 51.2 months (interquartile range, 29.5-79.8)
| Adjusted hazard ratio (95% CI) | ||
|---|---|---|
| Echocardiographic probability of PHNot associated | 1.51 (0.98–2.32) | |
| 0.512Adjusted hazard ratio (log scale) |
Hematologic progression among patients with right heart catheterization (exploratory)
- Hematologic progression among patients with right heart catheterization (exploratory): n=61 with right heart catheterization
- Hematologic progression among patients with right heart catheterization (exploratory): P =0.048
Original publication
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