Pulmonary vascular disease & thromboembolism
Optimal Combination of Right Ventricular Functional Parameters Using Echocardiography in Pulmonary Arterial Hypertension
Authors' conclusion
The combination models for RV function outperformed any single parameter in identifying the risk profile of patients with PAH.
Study context
- Population
- Patients with pulmonary arterial hypertension (PAH)
- Participants
- 70 patients
- Comparison
- Echocardiographic right ventricular (RV) functional parameters (single and combined models) for identifying PAH risk profile
- Low-riskn = 45reference
- Intermediate-high-riskn = 25
- Outcome
- Identification of risk profile (intermediate-high vs low risk) by RV parameters
Performance
As reported in the abstract
Identification of intermediate-high-risk profile
RV longitudinal strain (RVLS)/pulmonary artery systolic pressure (PASP)
0.895
AUC
Odds ratio (95% CI)P value
RVLS/PASP > −0.275Model 2, multivariate
20.63(4.62–92.11)
P < 0.001RVGWW > 90.5 mmHg%Model 2, multivariate
6.17(1.37–27.76)
P = 0.018- Addition of RV global wasted work (RVGWW) to models
- continuous net reclassification improvement 1.058 (95% CI 0.639–1.477); P < 0.001
- Model 1: only RVGWW (>90.5 mmHg%), RVLS (> −16.7%) and tricuspid annular plane systolic excursion (TAPSE) (<17.5 mm) remained significant
- all P < 0.05
- Model 1 outperformed every single RV parameter, with significantly larger AUC
- all P < 0.05
Original publication
Optimal Combination of Right Ventricular Functional Parameters Using Echocardiography in Pulmonary Arterial Hypertension. ESC Heart Fail. Published 15 March 2024. doi:10.
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