Heart failure & cardiomyopathies
Impact of Epicardial Adipose Tissue on Cardiac Function and Morphology in Patients with Diastolic Dysfunction
Authors' conclusion
Patients with diastolic dysfunction and increased EAT show more pronounced signs of diastolic functional failure and adverse structural remodelling. Despite similar morphological characteristics, patients with high EAT show significant cardiac functional impairment, in particular in the atria.
Study context
- Population
- Patients with exertional dyspnoea (NYHA ≥II), preserved EF (≥50%) and diastolic dysfunction (E/e' ≥ 8)
- Participants
- 68 patients
- Exposure
- High epicardial adipose tissue (EAT) vs low EAT
- Outcome
- Manifest heart failure with preserved ejection fraction (HFpEF) diagnosis
Main finding
As reported in the abstract
P = 0.029
- Higher HFA-PEFF and H2FPEFF scores and NT-proBNP with high EAT
- all P < 0.048
- Higher T1 times (adverse remodelling) with high EAT
- P < 0.001
- No differences in biventricular volumetry and LV mass
- all P > 0.074
Observational data: associations, not effects.
Original publication
Impact of Epicardial Adipose Tissue on Cardiac Function and Morphology in Patients with Diastolic Dysfunction. ESC Heart Fail. Published 13 March 2024. doi:10.
Summarised from the published abstract; every number is checked against it