Impact of hyperaemic stenosis resistance on long-term outcomes of stable angina in the ILIAS Registry
Authors' conclusion
The present study affirms the theoretical advantages of the HSR index for the detection of ischaemia-Âinducing coronary lesions in a large CCS population.
Study context
- Population
- Patients with chronic coronary syndromes and obstructive CAD with combined Doppler flow and pressure measurements
- Participants
- 853 patients1,107 vessels
- Exposure
- Hyperaemic stenosis resistance (HSR) vs fractional flow reserve (FFR) and coronary flow reserve (CFR)
- Outcome
- Identification of inducible ischaemia (diagnostic accuracy)
Methodological detailsdiagnostic and prognostic, multicentre
- Diagnostic and prognostic
- Multicentre
Main finding
As reported in the abstract
Inducible ischaemia
| Group | AUC |
|---|---|
| HSR | 0.71 |
| FFR | 0.66 |
| CFR | 0.62 |
AUC
HSR0.71
FFR0.66
CFR0.62
Observational data: associations, not effects.
Further findings
Target vessel failure, abnormal HSR · 5-year follow-up
| HR (95% CI) | P value | ||
|---|---|---|---|
| Abnormal HSRIndependent predictor | 3.80 (2.12–6.73) | P < 0.005 | |
| 0.10.31310Hazard ratio (log scale) |
Vessels deferred from revascularisation
- HSR seems to identify more accurately than FFR and/or CFR vessels that may benefit from revascularisation
Original publication
Impact of hyperaemic stenosis resistance on long-term outcomes of stable angina in the ILIAS Registry. EuroIntervention. Published 3 June 2024. doi:10.
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