Heart failure & cardiomyopathies
Impact of Improving Severity of Secondary Mitral Regurgitation on Survival
Main finding · Long-term survivalResult — go to the resultHazard ratio 0.55 95% CI 0.32–0.96Authors' conclusion
MT reduces SMR severity in 57% of the patients with severe SMR. A final SMR grade of ≤2+ is linked to improved survival, independently of the type of treatment they receive.
Study context
- Population
- Patients with severe secondary mitral regurgitation (SMR) and heart failure with reduced ejection fraction (HFrEF)435 evaluated
- Participants
- 158 patients
- Exposure
- Responders vs non-responders; Medical therapy (MT) alone vs mitral valve (MV) intervention plus MT
- Respondersn = 131
- Non-respondersn = 27reference
- Outcome
- Long-term survival
Main finding
As reported in the abstract
Hazard ratio
0.55
95% CI 0.32–0.96
P = 0.032
Respondersvs Non-responders
HR 0.55 (95% CI 0.32–0.96); P = 0.032
Observational data: associations, not effects.
Further findings
MR severity improvement, by intervention type · 30 days
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Survival by intervention type, overall populationMT alone n = 63; MV intervention plus MT n = 95 | 0.77 (0.48–1.26) | P = 0.3 | |
| Survival by intervention type, within respondersMT alone n = 36; MV intervention plus MT n = 95 | 1.03 (0.56–1.89) | P = 0.94 | |
| 0.512Hazard ratio (log scale) |
Original publication
Impact of Improving Severity of Secondary Mitral Regurgitation on Survival. ESC Heart Fail. Published 25 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →