Heart failure & cardiomyopathies
Impact of Increasing Referral for 99mTc-DPD Scintigraphy on Prognosis Across the Phenotypic Spectrum of Restrictive Cardiomyopathy
Authors' conclusion
There is strikingly high mortality among patients with negative 99mTc-DPD scintigraphy, equivalent to that of ATTR-CM.
Study context
- Population
- All-comers referred for 99mTc-DPD scintigraphy with echocardiography suggestive of ATTR-CM, Midlands Amyloidosis Service, 15 years528 referred
- Participants
- 477 participants
- Exposure
- ATTR-CM vs nonamyloid CM
- ATTR-CMn = 216
- Nonamyloid CMn = 261reference
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
5-year mortality · 5 years
P = 0.044
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Survival, ATTRwt-CM vs nonamyloid CM (age- and sex-adjusted Cox model) | 0.99 (0.98–1.38) | P = 0.96 | |
| 0.512Hazard ratio (log scale) |
Referrals from cardiologists over 5-year periods
- Increasing proportion of cardiologist referrals (47% vs 87% vs 96%)
- P < 0.001
Mortality by Perugini grade
- No difference in mortality according to Perugini grading
Original publication
Impact of Increasing Referral for 99mTc-DPD Scintigraphy on Prognosis Across the Phenotypic Spectrum of Restrictive Cardiomyopathy. JACC Adv. Published 22 October 2025. doi:10.
Summarised from the published abstract; every number is checked against it