Heart failure & cardiomyopathies
Quantitative Proteomics of Plasma-Derived Extracellular Vesicles Reveals a Plasminogen-Centered Protein Network in Transthyretin Cardiac Amyloidosis
Authors' conclusion
These exploratory findings highlight a plasmin/plasminogen-centered protein network linking fibrinolysis, complement activation, and vascular inflammation to ATTR pathophysiology, and suggest that plasma EV proteomics warrant further evaluation as a minimally invasive approach for disease monitoring and biomarker discovery in ATTR-CM.
Study context
- Population
- Patients with confirmed ATTR cardiomyopathy (ATTR-CM) (wild-type ATTR and variant ATTR) and patients with nonamyloid cardiomyopathy, referred to the Referral Center for Cardiac Amyloidosis (Henri Mondor Hospital, Créteil, France)ATTR+ group 41 · ATTR- group 24
- Participants
- 41 vs 24
- Comparison
- Plasma EV proteome in ATTR+ vs ATTR- patients
- ATTR+ groupn = 41
- ATTR- groupn = 24
Methodological detailsprospectively isolated, frequency-matched, exploratory
- Prospectively isolated
- Frequency-matched
- Exploratory
Main finding
As reported in the abstract
EV proteome signature
Proteins forming an interconnected network centered on plasmin/plasminogen
At least 18
Further findings
EV levels of transthyretin, plasminogen and alpha2-antiplasmin
- EV levels of transthyretin and plasminogen were elevated
- Level of alpha2-antiplasmin (plasmin's primary inhibitor) was low
Original publication
Quantitative Proteomics of Plasma-Derived Extracellular Vesicles Reveals a Plasminogen-Centered Protein Network in Transthyretin Cardiac Amyloidosis. JACC Adv. Published 8 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it