Valvular & structural heart disease
Impact of leaflet thrombosis on valve haemodynamic status after transcatheter aortic valve replacement
Authors' conclusion
In patients who had undergone successful TAVR, aortic valve haemodynamic status was not influenced by the presence of HALT.
Study context
- Population
- Patients after successful transcatheter aortic valve replacement (TAVR) randomised to edoxaban or DAPTCT-evaluated
- Participants
- 211 patients
- Comparison
- Hypoattenuated leaflet thickening (HALT) vs no HALT
- With HALTn = 30
- Primary endpoint
- Valve haemodynamics (aortic valve mean gradient) and predictors of haemodynamic SVD
- Follow-up
- 6 months
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Aortic valve mean gradient
P = 0.74
Further findings
Independent predictors of haemodynamic structural valve deterioration (SVD)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Older age | 1.138 (1.019–1.293) | P = 0.033 | |
| Aortic valve size ≤23 mm | 6.254 (2.230–20.569) | P = 0.001 | |
| Mean post-TAVR pressure gradient | 1.233 (1.123–1.371) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | With HALT |
|---|---|
| HALT incidence · 6 months | 14.2% |
- HALT incidence: 30 of 211 patients
Haemodynamic SVD incidence · 6 months
- SVD in 30 of 206 patients
- 14.6%
Independent predictors of haemodynamic SVD
- HALT not identified as a predictor of SVD
Original publication
Impact of leaflet thrombosis on valve haemodynamic status after transcatheter aortic valve replacement. Heart. Published 16 August 2023. doi:10.
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