Valvular & structural heart disease
Frequency, Predictors, and Clinical Impact of Valvular and Perivalvular Thrombus After Transcatheter Aortic Valve Replacement
Authors' conclusion
Subclinical aortic valve complex (valvular and perivalvular) thrombus was common in patients who had undergone successful TAVR. However, these imaging phenomena were not associated with new cerebral thromboembolism, neurologic or neurocognitive dysfunction, or adverse clinical outcomes.
Study context
- Population
- Transcatheter aortic valve replacement (TAVR) patients without an indication for chronic anticoagulation, with 6-month 4D CT evaluationwith 6-month CT
- Participants
- 211 patients
- Comparison
- Patients with vs without valvular or perivalvular thrombus after TAVR
- Primary endpoint
- Frequency of valvular (subclinical leaflet thrombus) and perivalvular thrombus on 4D CT
- Follow-up
- 6 months
Primary result
As reported in the abstract
Frequency of aortic valve complex thrombus
Thrombus at any aortic valve complex
91
43.1%
Leaflet thrombus
30
14.2%
Perivalvular thrombus
78
37.0%
Further findings
Predictors of thrombus
- Small maximum stent diameter at valve level and low body surface area independently predicted aortic valve complex and perivalvular thrombus
- Decreased renal function independently predicted leaflet thrombus
New cerebral lesions, neurologic or neurocognitive function, clinical outcomes
- No significant differences between patients with or without valvular or perivalvular thrombus
Original publication
Frequency, Predictors, and Clinical Impact of Valvular and Perivalvular Thrombus After Transcatheter Aortic Valve Replacement. JACC Cardiovasc Interv. Published 25 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →