Arrhythmias & electrophysiology
Impact of Left Atrial Strain on Clinical Outcomes in Patients with Permanent Pacemaker Implantation
Authors' conclusion
A decreased pre-procedure LASr was associated with long-term adverse outcomes after PPI use.
Study context
- Population
- Patients undergoing transvenous permanent pacemaker implantation (PPI), 2010–2020, excluding persistent AF, complete AV block, severe valvular disease, prior open-heart surgery172 analysed
- Participants
- 434 patients
- Outcome
- HF hospitalization or CV death
- Follow-up
- Median 4.7 years
Methodological detailssingle-centre, Pre-procedure LASr 28 ± 11%; mean age 78 ± 8 years; 42% men; sick sinus syndrome 64%, second-degree AV block 36%
- Single-centre
- Pre-procedure LASr 28 ± 11%; mean age 78 ± 8 years; 42% men; sick sinus syndrome 64%, second-degree AV block 36%
Main finding
As reported in the abstract
HF hospitalization or CV death, by pre-procedure LA reservoir strain (LASr)
Primary endpoint events, n (%)
23
13%
LASr independently associated with primary endpoint (multivariate Cox), HR per 1% decrease
1.08; 95% CI 1.02-1.15
P = 0.007
ROC cutoff of LASr for primary endpoint
21%; AUC 0.657
P = 0.004
Observational data: associations, not effects.
Further findings
Prognostic impact of LASr by pacing indication (sick sinus syndrome, AV block)
- Prognostic impact of LASr consistent across sick sinus syndrome and AV block
Original publication
Impact of Left Atrial Strain on Clinical Outcomes in Patients with Permanent Pacemaker Implantation. ESC Heart Fail. Published 29 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →