Heart failure & cardiomyopathies
Impact of Mitral Regurgitation in Patients with Acute Heart Failure: Insights from the RELAX-AHF-2 Trial
Authors' conclusion
In patients with AHF, moderate/severe MR was associated with a worse clinical profile but did not have an independent prognostic impact on clinical outcomes.
Study context
- Population
- Patients hospitalised for acute HF with known mitral regurgitation (MR) status1,810 [28.2%] moderate/severe MR
- Participants
- 6,420 patients
- Comparison
- Moderate/severe MR vs no/mild MR
- Moderate/severe MRn = 1,810
- Primary endpoint
- Composite of:
- CV death
- Rehospitalisation for HF/renal failure
- Follow-up
- 180 days
Primary result
As reported in the abstract
CV death or HF/renal failure rehospitalisation
Moderate/severe MR vs No/mild MREstimate (95% CI)P value
Unadjusted
crude HR 1.15(1.03–1.27)
P = 0.01Multivariable model
adjusted HR 1.03(0.91–1.17)
P = 0.65Further findings
HF/RF rehospitalisation alone · 180 days
- Similar findings to the composite
In-hospital course · index hospitalisation
- Moderate/severe MR associated with longer hospital stay, more residual dyspnoea, increased jugular venous pressure
Original publication
Impact of Mitral Regurgitation in Patients with Acute Heart Failure: Insights from the RELAX-AHF-2 Trial. Eur J Heart Fail. Published 13 March 2023. doi:10.
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