Valvular & structural heart disease
Impact of moderate or severe mitral and tricuspid valves regurgitation after transcatheter aortic valve replacement
Authors' conclusion
At long term follow up, moderate/severe TR, but not MR, is associated with higher mortality in patients underwent TAVR. Combined moderate/severe TR and MR had even worse mortality.
Study context
- Population
- Consecutive patients undergoing transcatheter aortic valve replacement (TAVR) at 3 academic tertiary care centres, 2012–2018
- Participants
- 52 / 1,015 / 86 / 985
- Exposure
- Moderate/severe mitral regurgitation (MR) or tricuspid regurgitation (TR) vs no/mild MR or TR
- Moderate/severe MRn = 52
- Mild/no MRn = 1,015reference
- Moderate/severe TRn = 86
- Mild/no TRn = 985reference
- Outcome
- All-cause mortality
- Follow-up
- 1 year and 5 years
Methodological details3 academic tertiary care centres, multivariable logistic and Cox regression
- 3 academic tertiary care centres
- Multivariable logistic and Cox regression
Main finding
As reported in the abstract
Moderate/severe MR
- 1-year mortality
- 15.38%
- 5-year mortality
- 61.4%
Mild/no MR
- 1-year mortality
- 14.09%
- 5-year mortality
- 49.5%
Moderate/severe TR
- 1-year mortality
- 26.7%
- 5-year mortality
- 68.3%
Mild/no TR
- 1-year mortality
- 13.2%
- 5-year mortality
- 48.7%
1-year mortality
Moderate/severe MR15.38%
Mild/no MR14.09%
Moderate/severe TR26.7%
Mild/no TR13.2%
5-year mortality
Moderate/severe MR61.4%
Mild/no MR49.5%
Moderate/severe TR68.3%
Mild/no TR48.7%
Moderate/severe TR vs Mild/no TROdds ratio (95% CI)P value
1-year mortality, multivariable cox regression
1.94(01.09–3.44)
P = 0.0235-year mortality, multivariable cox regression
1.46(1.092–1.952)
P = 0.011Observational data: associations, not effects.
Secondary outcomes
TAVR procedure success — Moderate/severe MR vs Mild/no MR
P = 0.283
| Outcome | Moderate/severe MR | Mild/no MR | Moderate/severe TR | Mild/no TR | P value |
|---|---|---|---|---|---|
| In-hospital mortalityModerate/severe MR vs Mild/no MR | 0 events | 1.08% | 0% | 1.1% | P = 0.450 |
| In-hospital mortalityModerate/severe TR vs Mild/no TR | P = 0.33 | ||||
| TAVR procedure successModerate/severe TR vs Mild/no TR | P = 0.54 |
Combined moderate/severe MR and TR, mortality · 5 years
- Even higher mortality vs either moderate/severe regurgitation alone or mild/no regurgitation
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of moderate or severe mitral and tricuspid valves regurgitation after transcatheter aortic valve replacement. Am Heart J. Published 13 November 2024. doi:10.
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