Heart failure & cardiomyopathies
Impact of Neighborhood Factors on Exercise Capacity in Children With Hypertrophic Cardiomyopathy
Authors' conclusion
Our study identified previously unrecognized environmental determinants of exercise capacity in children with HCM, with lower child opportunity index, increased urbanization, and lower neighborhood wealth independently associated with lower exercise performance. Programs designed to increase physical activity levels and exercise performance in children with HCM should account for neighborhood and economic factors.
Study context
- Population
- Children with hypertrophic cardiomyopathy (HCM) who underwent exercise stress testing at a single, children’s tertiary-care center between 2000 and 2023patients who met inclusion criteria, 23% (n=35) female
- Participants
- 155 children
- Exposure
- Child opportunity index and neighborhood measures (walkability index, rural-urban commuting area codes, index of concentration at the extremes, uniform crime reporting rates) in relation to peak oxygen consumption
- Outcome
- Peak oxygen consumption
Methodological detailssingle, children’s tertiary-care center, 2000 and 2023
- Single, children’s tertiary-care center
- 2000 and 2023
Main finding
As reported in the abstract
Mean peak oxygen consumption
2159±906 mm/min
Adjusted peak oxygen consumption
35.5±9.3 mL/kg per min
Observational data: associations, not effects.
Further findings
Patient characteristics
- Female
- 23% (n=35)
- Mean age at exercise stress testing
- 15.8±3.1 years
- High child opportunity index
- 30%, n=46
- Very high child opportunity index
- 35%, n=54
- Urban environment (rural-urban commuting area codes score, 1 or 2)
- 96.7%, n=150
Original publication
Impact of Neighborhood Factors on Exercise Capacity in Children With Hypertrophic Cardiomyopathy. Circ Heart Fail. Published 19 June 2025. doi:10.
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