Valvular & structural heart disease
Impact of Noncoaxial Transcatheter Aortic Valve Implantation on Clinical Outcomes
Authors' conclusion
Noncoaxial THV deployment is associated with impaired valve early safety and increased risk of bioprosthetic valve failure 1 year after TAVR.
Study context
- Population
- Consecutive patients undergoing transfemoral transcatheter aortic valve replacement (TAVR) with contemporary devices in the Bern transcatheter aortic valve implantation registry, February 2014 to June 2023patients undergoing TAVR, categorized by tertiles of coaxiality
- Participants
- 2,025 patients
- Exposure
- Highest tertile of THV axial angle vs coaxial valve positioning
- Outcome
- Axial angulation of the device relative to the native annulus
Methodological detailsretrospectively evaluated, consecutive patients, single registry (Bern)
- Retrospectively evaluated
- Consecutive patients
- Single registry (Bern)
Main finding
As reported in the abstract
Mean axial angulation
4.1°
Observational data: associations, not effects.
Further findings
| Outcome | Highest tertile of THV axial angle | Coaxial valve positioning | Estimate | P value | |
|---|---|---|---|---|---|
| Device early safety (Valve Academic Research Consortium-3)Reduced device early safety in highest tertile | 56.2% | 82.7% | aHR 0.67 (95% CI 0.59–0.76) | P < 0.001 | |
| Stage-2 bioprosthetic valve failure · 1-year follow-upHigher rates in highest tertile | 1.5% | 0.7% | HR 3.47 (95% CI 1.26–9.54) | P = 0.016 | |
| 0.10.31310Ratio (log scale) |
Independent predictors of noncoaxial valve implantation
- Left ventricle outflow tract calcium volume, predilatation, and valve type were independent predictors
Original publication
Impact of Noncoaxial Transcatheter Aortic Valve Implantation on Clinical Outcomes. JACC Adv. Published 22 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →