Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention
Main finding · Patient-oriented composite endpoint (PoCE), including cardiovascular death, non-fatal myocardial infarction, any revascularisation, and strokeResult — go to the resultPoCE incidence ratio 3.9 times higherStudy context
- Population
- Consecutive patients who underwent coronary computed tomography angiography (cCTA) before percutaneous coronary intervention (PCI) with current-generation drug-eluting stents (DES)patients followed for patient-oriented composite endpoint (PoCE)
- Participants
- 490 patients
- Exposure
- Association between coronary inflammation, as assessed by measuring pericoronary adipose tissue (PCAT) attenuation before PCI, and clinical outcomes of PCI using current-generation DES
- Outcome
- patient-oriented composite endpoint (PoCE), including cardiovascular death, non-fatal myocardial infarction, any revascularisation, and stroke
- Follow-up
- Median 1,540 days
Main finding
As reported in the abstract
PoCE incidence ratio
3.9 times higher
- Patients experiencing PoCE
- 77 of 490
- Presence of adverse plaque independently associated with PoCE, HR (multivariable)
- 2.05, 95% CI: 1.26-3.34; p=0.004
- Greater calcified plaque (CP) burden independently associated with PoCE, HR (multivariable)
- 1.04, 95% CI: 1.02-1.07; p=0.002
- Higher PCATRCA independently associated with PoCE, HR (multivariable)
- 2.20, 95% CI: 1.63-2.97; p<0.001
Observational data: associations, not effects.
Further findings
| Outcome | Patients with PoCE | Patients without PoCE |
|---|---|---|
| PCATRCA in patients with vs without PoCE | mean −76.3 (SD 6.4) HU | mean −82.5 (SD 8.1) HU |
- PCATRCA in patients with vs without PoCE — higher PCATRCA with PoCE
- p<0.001
Original publication
Impact of pericoronary adipose tissue attenuation on clinical outcomes after percutaneous coronary intervention. EuroIntervention. Published 2 June 2025. doi:10.
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