Pericoronary adipose tissue for predicting long-term outcomes
Authors' conclusion
In patients referred to CCTA for clinically suspected CAD, PCAT attenuation did not predict MACE during long-term follow-up.
Study context
- Population
- Symptomatic patients with coronary artery disease (CAD) who underwent coronary computed tomography angiography (CCTA) (mean age 63.3 ± 8.5 years, 54.9% men)1,561 lesions analysed
- Participants
- 483 patients
- Comparison
- Pericoronary adipose tissue (PCAT) attenuation as predictor of major adverse cardiac events (MACE)
- Outcome
- MACE predicted by PCAT attenuation
- Follow-up
- Median 9.5 years
Performance
As reported in the abstract
MACE per unit PCAT attenuation (per-patient, adjusted)
Adjusted hazard ratio (95% CI)P value
Average PCAT attenuation of all lesions
0.970(0.933–1.008)
P = 0.121PCAT attenuation of most obstructive lesion
0.992(0.961–1.024)
P = 0.622Highest PCAT attenuation lesion
0.981(0.946–1.016)
P = 0.285Per unit PCAT attenuation, as printed
Further findings
MACE by vessel-specific PCAT attenuation (adjusted)
| Adjusted HR (95% CI) | P value | ||
|---|---|---|---|
| Right coronary artery | 0.957 (0.830–1.104) | P = 0.548 | |
| Left anterior descending artery | 0.989 (0.954–1.025) | P = 0.550 | |
| Left circumflex artery | 0.739 (0.293–1.865) | P = 0.522 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Pericoronary adipose tissue for predicting long-term outcomes. Eur Heart J Cardiovasc Imaging. Published 6 August 2024. doi:10.
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