Valvular & structural heart disease
Impact of Residual Transmitral Mean Pressure Gradient on Outcomes After Mitral Transcatheter Edge-to-Edge Repair
Main finding · All-cause mortality or HF hospitalizationResult — go to the resultAdjusted hazard ratio 1.53 95% CI 1.03–2.26Authors' conclusion
In this single-center study, higher residual TMPG after M-TEER was associated with worse outcomes at intermediate- to long-term follow-up.
Study context
- Population
- Consecutive patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) at one institution, 2014–2022
- Participants
- 283 patients
- Exposure
- Predischarge transmitral mean pressure gradient (TMPG) quartile 4 vs quartiles 1 to 3 after M-TEER
- Outcome
- All-cause mortality or HF hospitalization
- Follow-up
- 3 years
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
All-cause mortality or HF hospitalization
Adjusted hazard ratio
1.53
95% CI 1.03–2.26
P = 0.034
Quartile 4 vs Quartiles 1 to 3
adjHR 1.53 (95% CI 1.03–2.26); P = 0.034
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | adjHR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality alone · 3 years | 1.68 (1.09–2.60) | P = 0.020 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Primary mitral regurgitation (MR) (subgroup): all-cause mortality or HF hospitalization, and all-cause mortality
- Primary MR, composite endpoint, adjHR
- 2.08 (1.15-3.77); P = 0.016 (95% CI)
- Primary MR, all-cause mortality, adjHR
- 2.70 (1.40-5.19); P = 0.003 (95% CI)
Secondary MR (subgroup)
- Association did not reach statistical significance in secondary MR
Predictor of increased TMPG after M-TEER: higher baseline TMPG
- Baseline TMPG coefficient
- 0.60 (0.40-0.70); P < 0.001 (95% CI)
Original publication
Impact of Residual Transmitral Mean Pressure Gradient on Outcomes After Mitral Transcatheter Edge-to-Edge Repair. JACC Adv. Published 4 September 2024. doi:10.
Summarised from the published abstract; every number is checked against it