Valvular & structural heart disease
Periprocedural Pulmonary Hypertension and Outcomes After Mitral Valve Transcatheter Edge-to-Edge Repair
Authors' conclusion
Periprocedural PH dynamics provide robust risk stratification after M-TEER, identifying low-risk patients with PH normalization and high-risk subsets with residual or new-onset PH, requiring closer surveillance and procedural optimization. Registration Treatment and Prognosis of Heart Valve Registry; UMIN-ID: UMIN000023653.
Study context
- Population
- Patients with severe mitral regurgitation treated with M-TEER, with paired echocardiographic tricuspid regurgitation pressure gradient (TRPG) dataenrolled, 3,484 with paired echocardiographic TRPG data
- Participants
- 3,764 patients
- Exposure
- Periprocedural pulmonary hypertension (PH) patterns vs no PH
- No PHn = 1,432reference
- Normalized PHn = 763
- New-onset PHn = 298
- Residual PHn = 991
- Outcome
- Cardiovascular death or heart failure hospitalization
- Follow-up
- 2 years
Methodological detailsprospectively enrolled
- Prospectively enrolled
Main finding
As reported in the abstract
Each group vs no PHEstimate (95% CI)
Normalized PH
adjusted HR 0.98(0.78–1.24)
New-onset PH
HR 1.46(1.10–1.93)
Residual PH
HR 1.37(1.13–1.68)
Observational data: associations, not effects.
Further findings
Predictors of residual and new-onset PH (multivariable logistic regression)
- Severe tricuspid regurgitation, baseline TRPG >50 mm Hg, and tricuspid annular dilation predicted residual PH
- Residual mitral regurgitation and postprocedural transmitral gradients >5 mm Hg predicted new-onset PH
Original publication
Periprocedural Pulmonary Hypertension and Outcomes After Mitral Valve Transcatheter Edge-to-Edge Repair. JACC Cardiovasc Interv. Published 26 October 2026. doi:10.
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