Pulmonary vascular disease & thromboembolism
Impact of Right Ventricular Pressure Overload on Myocardial Stiffness Assessed by Natural Wave Imaging
Authors' conclusion
Both RV early-systolic and early-diastolic myocardial stiffness show significant increase in response to pressure overload.
Study context
- Population
- Rodent models and children with right ventricular (RV) pressure overload vs controls14 children
- Participants
- 6 / 7 / 6 / 7 / 7
- Comparison
- RV pressure overload vs control
- Pulmonary artery bandingn = 6
- Sugen hypoxian = 7
- Shamn = 6reference
- RV pressure overload (children)n = 7
- Control subjects (children)n = 7reference
- Outcome
- RV natural wave velocity (NWV) after tricuspid (TVC) and pulmonary valve closure (PVC), and its correlation with RV hemodynamic parameters
- Follow-up
- 6 weeks postoperatively (rats)
Methodological detailsrodent models (randomised), prospective paediatric cohort, age-matched controls
- Rodent models (randomised)
- Prospective paediatric cohort
- Age-matched controls
Main finding
As reported in the abstract
RV NWV (rats) · 6 weeks
| Group | Natural wave velocity (NWV) after TVC | NWV after PVC |
|---|---|---|
| Pulmonary artery banding | 4.99 ± 0.27 m/s | 5.03 ± 0.32 m/s |
| Sugen hypoxia | 4.89 ± 0.26 m/s | 4.84 ± 0.30 m/s |
| Sham | 2.83 ± 0.15 m/s | 2.72 ± 0.34 m/s |
Natural wave velocity (NWV) after TVC
Pulmonary artery banding4.99 ± 0.27 m/s
Sugen hypoxia4.89 ± 0.26 m/s
Sham2.83 ± 0.15 m/s
NWV after PVC
Pulmonary artery banding5.03 ± 0.32 m/s
Sugen hypoxia4.84 ± 0.30 m/s
Sham2.72 ± 0.34 m/s
- NWV after TVC correlated with RV dP/dtmax
- r = 0.75; P < 0.005
- NWV after TVC correlated with RV Ees
- r = 0.81; P < 0.005
- NWV after PVC correlated with RV end-diastolic pressure
- r = 0.65; P < 0.01
Further findings
RV NWV (children)
- NWV after both right valves closure higher in RV pressure overload than in healthy volunteers
- P < 0.01
- NWV after PVC correlated with RV E/E'
- r = 0.81; P = 0.008
- NWV after PVC correlated with RV chamber stiffness
- r = 0.97; P = 0.03
Original publication
Impact of Right Ventricular Pressure Overload on Myocardial Stiffness Assessed by Natural Wave Imaging. JACC Cardiovasc Imaging. Published 21 August 2024. doi:10.
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