Pulmonary vascular disease & thromboembolism
Prognostic utility of exercise cardiovascular magnetic resonance in patients with systemic sclerosis-associated pulmonary arterial hypertension
Authors' conclusion
Exercise CMR assessment of RV size and function may help identify SSc-PAH patients with poorer prognosis amongst intermediate risk cohorts, even when resting CMR appears reassuring, and could offer added value to clinical PH risk stratification.
Study context
- Population
- Patients with systemic sclerosis complicated by pulmonary arterial hypertension (SSc-PAH) categorised as intermediate risk
- Participants
- 50 patients
- Exposure
- Exercise cardiovascular magnetic resonance (CMR) vs resting CMR for prognosis
- Outcome
- Mortality
- Follow-up
- Median 2.1 years (range 0.1-4.6)
Methodological detailsMost patients had normal resting CMR right ventricular (RV) size and function
- Most patients had normal resting CMR RV size and function
Main finding
As reported in the abstract
median follow-up 2.1 years
Deaths
9
18%
Peak exercise RVESVi the only CMR metric to predict prognosis on stepwise Cox regression; optimal threshold for favourable outcome
< 39 mL/m²
Observational data: associations, not effects.
Further findings
Cardiopulmonary exercise measures
- Ventilatory efficiency and resting VO2 predictive of mortality; peak VO2, peak cardiac output and peak tissue oxygen extraction not predictive
Original publication
Prognostic utility of exercise cardiovascular magnetic resonance in patients with systemic sclerosis-associated pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. Published 19 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →