Acute cardiac care & resuscitation
Impact of sedation depth on neurological outcome in post-cardiac arrest patients – A retrospective cohort study
Main findingResult — go to the resultOdds ratio 1.82 95 % CI 1.02–3.23Authors' conclusion
Lighter sedation strategies during TTM after cardiac arrest might improve outcome and should be further investigated.
Study context
- Population
- Post-cardiac arrest patients receiving targeted temperature management (TTM) on a medical ICU, 08/2016–03/2021
- Participants
- 403 patients
- Exposure
- RASS-target −4 vs RASS-target −5 during TTM
- RASS-target −4n = 118
- RASS-target −5n = 285reference
- Outcome
- Favourable neurological outcome (Cerebral Performance Category (CPC) 1 or 2)
- Follow-up
- ICU discharge
Methodological detailsbefore-and-after registry study, single medical ICU
- Before-and-after registry study
- Single medical ICU
Main finding
As reported in the abstract
Odds ratio
1.82
95 % CI 1.02–3.23
P = 0.042
Events by group
RASS-target −4vs RASS-target −5
OR 1.82 (95 % CI 1.02–3.23); P = 0.042
Observational data: associations, not effects.
Further findings
| Outcome | OR for 30-day survival (CI) | P value | |
|---|---|---|---|
| 30-day survival · 30-day survival associated with RASS-target −4 | 1.81 (1.01–3.26) | P = 0.047 | |
| 0.20.5125OR for 30-day survival (log scale) |
ICU survival · ICU discharge
- ICU survival was similar in both groups
Original publication
Impact of sedation depth on neurological outcome in post-cardiac arrest patients – A retrospective cohort study. Resuscitation. Published 2 December 2024. doi:10.
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