Impact of Social Determinants of Health and Lifestyle on Association Between Lipoprotein(a) and Cardiovascular Events
Authors' conclusion
SDOH and lifestyle factors associated with risk for MI and stroke but did not largely impact the association between Lp(a) and cardiovascular events.
Study context
- Population
- US cohorts (ARIC, MESA)
- Participants
- 15,072 vs 6,822
- Comparison
- Association of Lp(a) with myocardial infarction (MI) and stroke, before and after adjustment for social determinants of health (SDOH) and LS7 scores
- ARICn = 15,072
- MESAn = 6,822
- Outcome
- Time until first MI or stroke
Methodological detailsARIC and MESA, sequential multivariable Cox proportional hazard analysis
- ARIC and MESA
- Sequential multivariable Cox proportional hazard analysis
Pooled result
As reported in the abstract
Association of Lp(a) with MI and stroke
- ARIC · Lp(a) and MI; adjusted for age, gender, race, ethnicity, non-HDL-C
- HR 1.10; P < 0.001
- MESA · Lp(a) and MI; adjusted for age, gender, race, ethnicity, non-HDL-C
- HR 1.11; P = 0.001
- ARIC · Lp(a) and stroke; adjusted for age, gender, race, ethnicity, non-HDL-C
- HR 1.07; P < 0.001
- MESA · Lp(a) and stroke; adjusted for age, gender, race, ethnicity, non-HDL-C
- HR 0.97; P = 0.53
- ARIC · Lp(a) and MI; models with SDOH and LS7
- HR 1.08; P < 0.001
- MESA · Lp(a) and MI; models with SDOH and LS7
- HR 1.10; P = 0.001
- ARIC · Lp(a) and stroke; models with SDOH and LS7
- HR 1.06; P = 0.002
- MESA · Lp(a) and stroke; models with SDOH and LS7
- HR 0.96; P = 0.37
Further pooled results
| Outcome | HR | P value |
|---|---|---|
| Each additional SDOH and MI/stroke — ARIC · MI | 1.04 | P = 0.01 |
| Each additional SDOH and MI/stroke — MESA · MI | 1.08 | P = 0.003 |
| Each additional SDOH and MI/stroke — MESA · stroke | 1.03 | P = 0.41 |
| Each additional LS7 point and MI/stroke — ARIC · MI | 0.88 | P < 0.001 |
| Each additional LS7 point and MI/stroke — MESA · MI | 0.85 | P < 0.001 |
| Each additional LS7 point and MI/stroke — ARIC · stroke | 0.91 | P < 0.001 |
| Each additional LS7 point and MI/stroke — MESA · stroke | 0.86 | P < 0.001 |
Original publication
Impact of Social Determinants of Health and Lifestyle on Association Between Lipoprotein(a) and Cardiovascular Events. JACC Adv. Published 12 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it